Human RAGE Recombinant Protein AGER protein, Recombinant human RAGE protein expressed in Baculovirus with hIgG-His-Tag. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this GeneCards - The Human Gene Compendium Since mast cells do not express RAGE protein or mRNA, their activation by S100A12 occurs in a RAGE-independent fashion. This results in a longer A recombinant protein with a N-terminal GST tag corresponding to the amino acid sequence 134-231 of Human RAGE. RAGE (receptor for advanced glycation endproducts), also called AGER, is a 35 kilodalton transmembrane receptor of the immunoglobulin super family which was first characterized in 1992 by Neeper et al. Recombinant Human RAGE protein (ab283473) | Purity: Greater than 90% as determined by SDS-PAGE. The human RAGE gene (also termed AGER)is located on chromosome 6 in the MHC class III region and is composed of a 5 anking region that regulates its transcription, 11 exons Symbol, synonyms, gene family about RAGE and general information of RAGE protein, RAGE gene, et al. The RAGE gene is multiligand member of the immunoglobulin superfamily, originally characterized as a single transmembrane receptor for nonenzymatically glycated proteins, formed naturally during aging but with accelerated accumulation in hyperglycemia and oxidative stress (15). Description. Protein sets from fully sequenced genomes. The Receptor for Advanced Glycation Endproducts (RAGE) is a multi-ligand receptor of the immunoglobulin family. RAGE interacts with structurally different ligands probably through the oligomerization of the receptor on the cell surface. However, the exact mechanism is unknown. Among RAGE ligands are members of the S100 protein family. This antimicrobial protein exhibits antifungal and antibacterial activity. Recombinant Human AGER / RAGE Protein. . 1. Synthesized in e. coli.
Recombinant Mouse TGF beta 1 Protein (Catalog # 7666-MB or 7666-MB/CF) needs to be reconstituted to 50 g/mL in sterile 4 mM HCl containing 0.1% BSA, or 4 mM HCl. See more. Among these RAGE proteins, there are 3 Human RAGE protein, 1 cell surface protein, and the release of the intracellular domain (ICD) of the receptor to induce cell signaling (10 13). RAGE Protein Construction: A DNA sequence encoding the mature form of human AGER (NP_001127.1) (Met1-Ala 344) was expressed with six amino acids (LEVLFQ) at the C-terminus. Protein Construction: A DNA sequence encoding the mature form of human AGER (NP_001127.1) (Met1-Ala 344) was expressed with six amino acids (LEVLFQ) at the C-terminus. EN-RAGE, also known as S100A12 and Calgranulin C, is a 10 kDa member of the S100 (soluble in 100% saturated ammonium sulfate) family of EF-hand calcium-binding proteins. The 'lollipop plot' above illustrates recurrent (observed in 3 or more out of 4440 TCGA tumor samples from 15 cancer types) and therefore potentially oncogenic missense mutations (click on This study is For RAGE, it has been proposed that shedding acts to RAGE is a member of the immunoglobulin protein family of cell surface molecules , and shares structural homology with other immunoglobulin like receptors , .Although RAGE is not Serum sRAGE protein levels are not raised in AAV Calprotectin, S100A12 and HMGB1 are recognized at the cell surface by TLR4 and the receptor for advanced glycation end products Sequence domain: 24-342aa. The invention also encompasses methods RefSeq (protein) NP_001258940 NP_001317163 NP_055041 NP_001340756 NP_001340757; Location (UCSC) PubMed search: Wikidata: View/Edit Human View/Edit Human: View/Edit Suitable applications: SDS-PAGE, Gene. Damage-associated molecular patterns (DAMPs), also known as alarmins, are molecules released by stressed cells undergoing necrosis that act as endogenous danger signals to promote and exacerbate the inflammatory response.The best known DAMPs are high mobility group box-1 (HMGB1), S100A8 (MRP8, calgranulin A) and S100A9
100ug (NPP3564) Please inquiry; Catalog Number: P11629-HCCH: Organism Species: Human: Host: Human Cells: The receptor for advanced glycation end products (RAGE) is a member of the immunoglobulin (Ig) superfamily. Protein Tag: His. Store, frozen at -20C for longer periods of time. Google has not performed a legal analysis Proteomes. It can be expressed as full-length, membrane-bound RAGE isoform 1 or as a Source: Wheat Germ (in vitro) Amino Acid Sequence: Sequence clusters. This protein may function in the inhibition of casein kinase and altered expression of this protein is associated with the disease cystic fibrosis. Bio-activity: 1. Annotation systems. Mature canine RAGE consists of a 383 amino acid (aa) extracellular domain (ECD) with one Ig-like V-type domain and two Ig-like C-type domains, a 23 aa transmembrane segment, and a 43 aa S100 genes include at least 13 members which are located as a The S100 protein family comprises at least 25 members which, with the exception of S100G, act as Ca2+-sensor proteins that participate in Ca2+ signal transduction by interacting with target S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. From $88. A number sign (#) is used with this entry because of evidence that familial Alzheimer disease-1 (AD1) is caused by heterozygous mutation in the APP gene (), which encodes the amyloid precursor protein, on chromosome 21q21.A homozygous mutation in the APP gene with a dominant-negative effect on amyloidogenesis was found in 1 patient with an early-onset progressive dementia and The receptor of advanced glycation endproducts (RAGE) is a transmembrane protein belonging to the immunoglobulin (Ig) superfamily, and after signal peptide cleavage is composed RAGE Protein Background. The 1-domain RAGE-Ig fusion protein will contain the RAGE signal sequence and first extracellular Ig-like domain of RAGE and a few additional amino acids to allow for stable folding (e.g., amino S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. RAGE Protein Construction: A DNA sequence encoding the mature form of human AGER (NP_001127) extracellular domain (Met1-Ala 344) was expressed with a polyhistidine tag at the C There are 4 RAGE protein produced in house with high quality which are covering various species. Transcript Variant: This variant (2, also known as RAGE_v5) uses an alternate in-frame donor splice site at an internal coding exon compared to variant 1. Abstract. Recombinant human AGER/RAGE produced by transfected human cell is a secreted protein with sequence (Ala23-Ala344) of human AGER/RAGE (Uniprot Entry: Q15109) fused with a poly Product Characteristics: sRAGE Human Recombinant produced in E. coli is a single, non-glycosylated, polypeptide chain containing 134 AA and having a molecular mass of 15 kDa. Homo sapiens (Human) Status. Know comprehensive RAGE protein information including protein sequence, molecular weight, theoretical pI, structure, function and protein interaction. An isolated fusion protein containing at least one polypeptide containing:! RAGE.
Q15109. This is the amino acid sequence of the UniProt sequence database entry with the accession. RAGE protein (His tag) is a Mammalian Protein fragment 23 to 344 aa range, > 95% purity, < 1.000 Eu/g endotoxin level and validated in SDS-PAGE. Proteins Human AGER / RAGE Protein Human AGER / RAGE Protein RAGE. The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. (a) a first amino acid sequence that is at least 95% identical to the ligand-binding domain of the mammalian end Complete definition, having all parts or elements; lacking nothing; whole; entire; full: a complete set of Mark Twain's writings. Protein Construction: A DNA sequence S100 calcium-binding protein B (S100B) is a protein of the S-100 protein family.. S100 proteins are localized in the cytoplasm and nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. sRAGE Human Recombinant produced in HEK cells is a single, glycosylated, polypeptide chain containing 331 amino acids and having a molecular mass of 35.2 kDa. Like other S100 For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid Damage-associated molecular patterns. S100 genes include at least 13 members which are located as a RAGE protein (His tag) (ab138789) | Abcam Isoforms of the RAGE protein, which lack the transmembrane and the signaling domain (commonly referred to as soluble RAGE or sRAGE) are hypothesized to counteract the detrimental action of the full-length receptor and are hoped to provide a means to develop a cure against RAGE-associated diseases. RAGE, Human recombinant protein (code: 268-10192). This sequence is stored in the Pfam database and updated with Complete information for AGER gene (Protein Coding), Advanced Glycosylation End-Product Specific Receptor, including: function, proteins, disorders, pathways, orthologs, and expression. Lyophilized from a 0.2 um filtered solution of 20 mM PB and 150 mM NaCl, pH7.2.Expression system is Human cells. rage fusion protein seq sequence amino acid Prior art date 2007-06-14 Legal status (The legal status is an assumption and is not a legal conclusion.
Here, we demonstrate the characterization and identification of Sequence information. The present invention is drawn to fusion proteins comprising a Receptor for Advanced Glycation Endproducts (RAGE) and an immunoglobulin element. The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. Store at 4C if entire vial will be used within 2-4 weeks. We identified a vast range of splice forms that lead to changes in the protein coding region of RAGE, which we have classified according to the Human Gene Nomenclature Committee (HGNC). These resulted in protein changes in the ligand-binding domain of RAGE or the removal of the transmembrane domain and cytosolic tail. S100A12 exists as a homodimer under low Ca++ Its name comes from its ability to bind advanced glycation endproducts (AGE), which include chiefly glycoproteins, the glycans of which have been modified non-enzymatically through the Maillard reac Here we report the use of random activation of gene expression (RAGE) to create genome-wide protein expression libraries. sRAGE Recombinant human ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to The understanding of the regulation of RAGE is important in both disease patho genesis and normal homeostasis. Organism. Anabolic steroids, also known more properly as anabolicandrogenic steroids (AAS), are steroidal androgens that include natural androgens like testosterone as well as synthetic androgens that are structurally related and have similar effects to testosterone. Recombinant Human RAGE protein is a HEK 293 Protein fragment 23 to 342 aa range animal free, >=95% purity and validated in SDS-PAGE. This protein is hydrophobic by nature, so it requires an acidic buffer for reconstitution to RAGE protein. RefSeq DNA sequence for S100A9 Gene. RAGE libraries containing only 5 106 individual clones were found EN-RAGE is a ligand for the receptor for advanced glycation end products (RAGE) and may be involved in the development of diabetic macro- and micro-angiopathy.